Luigi Di Iorio began studying the cello with Evangelista Frascarelli, then he was a student at the "Luisa D'Annunzio" Conservatory of Music in Pescara with Massimo Magri. He continues his training in Pescara and Rome under the guidance of Luigi Piovano, conductor and first cello soloist of the Orchestra of the National Academy of Santa Cecilia.
He began orchestral practice at the age of sixteen, collaborating with numerous orchestras and from 1997 to 2010 permanently at the Teatro Marrucino in Chieti - Teatro Lirico d'Abruzzo in symphonic, opera and choreutic programming, playing the role of first cello many times.
He played under the direction of Riccardo Muti, Gianluigi Gelmetti, Massimo de Bernart, Piero Bellugi, Giorgio Gaslini, Donato Renzetti performing in Italy, Belgium, Israel, Palestine, Canada, Andorra. He has participated in the realization of numerous recordings for prestigious record companies such as Bongiovanni and Naxos and in several concerts broadcast live on television, also worldwide, for RAI and RAI Sat International.
He was Artistic Secretary of the "SIMT - Italian Society of Music and Theater" and of the international music festival "Majellarte". He held the position of Director of Production and Musical Services of the Marrucino Theater in Chieti - Teatro Lirico d'Abruzzo realizing over thirty productions including operas, ballets, symphonic concerts, and of the summer festival "Mozartian Week" with over one hundred and fifty musical performances for editions from 2007 to 2009.
He attended the higher course in orchestral conducting at the International Music Academy of Imola with Marco Boni, honorary conductor of the Concertgebouw Chamber Orchestra of Amsterdam. From 2011 to 2016 he attended masterclasses in orchestral conducting with Dominique Rouits, professor at the Ecole Normale in Paris, with Wolfgang Doerner at the European College of Music, conducting the Bucharest National Radio Orchestra and in Lviv with Ferdinando Nazzaro, professor of the Conservatory of Santa Cecilia in Rome, obtaining participation and merit diplomas.
He regularly collaborates with Luigi Piovano with whom he has participated in numerous productions with the “Strings Orchestra of the National Academy of Santa Cecilia”, the “Abruzzese Symphony Orchestra”, the “Marchigiana Philarmonic Orchestra", “Sicilian Symphony Orchestra”, the “Easter Festival” in Montepulciano and the “Massimo Bellini Theater” in Catania.
In 2019 he is founder and Artistic Secretary of "Oltre la Serratura festival" which takes place in the Magistral Villa of the Order of Malta in Rome under the patronage of His Eminent Highness the Prince and Grand Master; occasion on which he began a fruitful collaboration with the "RomÆnsemble" orchestra.
From 2020 he participates in the project "A Stradivarius for young people" which is held annually in the Villa Serbelloni in Bellagio, guest of the "Rockefeller Foundation", where he directs the Accademia Concertante in Milan.
In December 2021 he made his debut on the podium of the "Giuseppe Verdi" Orchestra of Milan with two replicas of the ballet "The Nutcracker" by P.I. Tchaikovsky in the "Crescendo in musica" season.